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Although wet wipes are marketed to provide a better clean down there, especially after going No. 2, you’re generally not supposed to wipe with wet wipes as they can actually be more harmful than helpful.  “The use of wet wipes is a common cause of perianal dermatitis (a rash around your butthole),” said Dr. Alex Elias, a board-certified female colorectal surgeon in Bakersfield, California.