While this didn’t happen, it does have an origin; according to the film’s writer-director, the late John Singleton, it was actually a joke (not the most tasteful joke, I know) he started when they were filming. The backstory is that both he and Tupac had HUGE crushes on Jackson (who was not interested in either of them, ’cause she was secretly married at the time), and he would jokingly say, “We’re gonna have to get you an AIDS test for you to kiss my actress!” as a way to one-up Tupac. The joke became a rumor even before the movie was released.
Also, it’s important to note that HIV/AIDS had been a known disease for over a decade-plus when the movie was filmed — it was already a known fact that you could not transmit the disease through kissing, so it doesn’t even make sense.
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