1.
T.R. Knight famously asked for his character, George O’Malley, to be killed off the hit medical series, Grey’s Anatomy, in Season 6. He explained that his departure was due to his character’s lack of screen time, his “breakdown of communication” with show runner Shonda Rhimes, and homophobic comments he received from one of his fellow co-stars, Isaiah Washington.
He also revealed he struggled with the drastic changes in his storyline leading up to Season 6, which further dissuaded him from returning to the series. After all the outcry and controversy with fans, Knight stated that there “comes a time when it’s so clear that moving on is the best decision.”
2.
Coincidentally, Grey’s Anatomy star Katherine Heigl also left the show in Season 6. She explained a huge dissatisfaction with her character and storyline, even withdrawing herself from Emmy consideration that year because of it.
Heigl shared that her character had been going on a downward spiral ever since Season 5 and felt she didn’t deserve the Emmy nomination for the following season. She stated that she hadn’t been given enough material to warrant such consideration, which furthered the tension between her and show runner, Shona Rhimes, ultimately leading to her departure.
3.
In a 2012 interview, Mandy Patinkin revealed that he left the hit drama series Criminal Minds due to its aggressive subject matter regarding the harsh treatment and violence of women, which he described as a huge emotional burden for himself.
The show often depicted tough subject matters along with extremely despicable crimes that left some audiences appalled, turning away some viewers from its violent, disturbing nature. After his sudden departure in Season 3, Patinkin stated that joining Criminal Minds was the “biggest public mistake he ever made.”